Discovering immune mechanisms that contribute to progressive pulmonary fibrosis

Dr. Sarah Holton, acting instructor (Pulmonary, Critical Care, and Sleep Medicine) is the recipient of a K23 award from NIH/NHLBI for mentored patient-oriented research career development.

This 5-year award will support her efforts to define the immune cell populations that lead to progression of fibrosis in Interstitial Lung Disease.

She will use high dimensional flow cytometry and single cell and spatial transcriptomics to define these populations in the blood and the lung and relate them to clinical outcomes in two cohorts of patients.

Her mentorship and advisory team includes Drs. Carmen Mikacenic, Mark Wurfel and Ganesh Raghu (Pulmonary, Critical Care and Sleep Medicine), Jessica Hamerman (Immunology), Leila Zelnick (Nephrology), and Hannah DeBerg (BRI, Bioinformatics).